Hemorrhage (bleeding): Blood leaking out of blood vessels may be obvious, as from a wound penetrating the skin. Internal bleeding (such as into the intestines, or after a car accident) may not be immediately apparent.

Hematoma: A collection of blood inside the body tissues. Internal bleeding often causes a hematoma.

Leukemia: A form of blood cancer, in which white blood cells multiply abnormally and circulate through the blood. The abnormal white blood cells make getting sick from infections easier than normal.

Multiple myeloma: A form of blood cancer of plasma cells similar to leukemia. Anemia, kidney failure and high blood calcium levels are common in multiple myeloma.

Lymphoma: A form of blood cancer, in which white blood cells multiply abnormally inside lymph nodes and other tissues. The enlarging tissues, and disruption of blood’s functions, can eventually cause organ failure.

Anemia: An abnormally low number of red blood cells in the blood. Fatigue and breathlessness can result, although anemia often causes no noticeable symptoms.

Hemolytic anemia: Anemia caused by rapid bursting of large numbers of red blood cells (hemolysis). An immune system malfunction is one cause.

Hemochromatosis: A disorder causing excessive levels of iron in the blood. The iron deposits in the liver, pancreas and other organs, causing liver problems and diabetes.

Sickle cell disease: A genetic condition in which red blood cells periodically lose their proper shape (appearing like sickles, rather than discs). The deformed blood cells deposit in tissues, causing pain and organ damage.

Bacteremia: Bacterial infection of the blood. Blood infections are serious, and often require hospitalization and continuous antibiotic infusion into the veins.

Malaria: Infection of red blood cells by Plasmodium, a parasite transmitted by mosquitos. Malaria causes episodic fevers, chills, and potentially organ damage.

Thrombocytopenia: Abnormally low numbers of platelets in the blood. Severe thrombocytopenia may lead to bleeding.

Leukopenia: Abnormally low numbers of white blood cells in the blood. Leukopenia can result in difficulty fighting infections.

Disseminated intravascular coagulation (DIC): An uncontrolled process of simultaneous bleeding and clotting in very small blood vessels. DIC usually results from severe infections or cancer.

Hemophilia: An inherited (genetic) deficiency of certain blood clotting proteins. Frequent or uncontrolled bleeding can result from hemophilia.

Hypercoaguable state: Numerous conditions can result in the blood being prone to clotting. A heart attack, stroke, or blood clots in the legs or lungs can result.

Polycythemia: Abnormally high numbers of red blood cells in the blood. Polycythemia can result from low blood oxygen levels, or may occur as a cancer-like condition.

Deep venous thrombosis (DVT): A blood clot in a deep vein, usually in the leg. DVTs are dangerous because they may become dislodged and travel to the lungs, causing a pulmonary embolism (PE).

Myocardial infarction (MI): Commonly called a heart attack, a myocardial infarction occurs when a sudden blood clot develops in one of the coronary arteries, which supply blood to the heart.